Wistar Han Aryl Hydrocarbon Receptor (AhR)
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چکیده
Unknown, but the effects seem limited. Rats homozygous for the mutant allele have a dramatically increased LD50 for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and PCDD (penta-), but not HCDD (hexa-). Overall, the tissue distribution and excretion of TCDD in rats homozygous for the AhR mutation is similar to that of the Long-Evans rat, which was used as a dioxin-sensitive control strain. Reproductive performance of the Wistar Han rat does not appear affected, nor does there appear to be any effect on lifespan. Other than alterations of some responses to dioxin, no impact has been reported since the trait (mutation) was first described in the literature in 1986.
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